Pyridines and derivatives
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- (19)
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- (1)
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- (54)
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- (17)
- (4)
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- (5)
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- (7)
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- (5)
- (10)
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- (12)
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- (39)
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- (11)
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Medchemexpress LLC Tolcapone | 134308-13-7 | 99.9% | 273.24 | 5 MG
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Tolcapone (Ro 40-7592) is a selective, potent, and orally active COMT inhibitor with an IC50 of 773 nM. It inhibits α-syn and Aβ42 oligomerization and fibrillogenesis, and can induce oxidative stress, causing apoptosis and ROS production in cancer cells. It is used for research related to cancer and neurological diseases, such as Parkinson's disease and neuroblastoma.
- Inhibits α-synuclein fibrillization.
- Inhibits α-syn seed-induced polymerization.
- Inhibits Aβ42 fibrillization.
- Inhibits Aβ42 seed-induced polymerization.
- Protects PC12 cells against α-syn and Aβ42-induced toxicity.
- Induces apoptosis in neuroblastoma cells.
- Increases reactive oxygen species levels in cells.
- Decreases the ATP per cell ratio in neuroblastoma cells.
- Inhibits tumor growth and prolongs survival in xenograft mouse models.
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![Alkali Scientific Cellulase [Onozuka R 10], 5 G](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000660379.jpg-250.jpg)
Alkali Scientific Cellulase [Onozuka R 10], 5 G
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Cellulase Onozuka R10, 5 g, is an enzyme grade reagent designed to catalyze the breakdown of cellulose in plant cell walls. It is commonly used in a variety of research applications, including plant cell culture, genetic engineering, and the extraction of intracellular components. By degrading cellulose, this cellulase enzyme facilitates the release of valuable compounds, making it ideal for experiments in plant biology, biochemistry, and agriculture. It is also employed in industrial applications, such as biofuel production and the processing of plant materials. This high-purity cellulase enzyme is a crucial tool in both laboratory research and commercial applications that require efficient cell wall digestion.
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Alkali Scientific Flurprimidol, 25 Mg
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Flurprimidol is a plant growth regulator used to control the growth of plants by inhibiting gibberellin biosynthesis. Available in 25 mg amounts, it is used in laboratory settings for controlling excessive plant growth and promoting compact plant forms. Flurprimidol is often used in plant tissue culture experiments to regulate the growth of plant tissues and enhance the success of culture protocols. By inhibiting gibberellin, flurprimidol helps maintain desirable plant morphology, making it useful for both research and commercial plant breeding. It is widely used in controlled environments to achieve optimal plant size and shape, particularly in ornamental and agricultural crops.
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Alkali Scientific Cefoperazone, Sodium Salt, 5 Grams
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Cefoperazone sodium salt is a broad-spectrum cephalosporin antibiotic supplied in a 5 gram laboratory-grade format for research and microbiological applications. It is effective against a wide range of Gram-negative and certain Gram-positive bacteria by inhibiting bacterial cell wall synthesis. This compound is commonly used in selective media formulations, antimicrobial susceptibility testing, and microbiological research where controlled bacterial inhibition is required. The sodium salt form provides improved solubility in aqueous solutions, making it suitable for laboratory preparation and experimental workflows. It is widely utilized in pharmaceutical, clinical, and research laboratories for antimicrobial studies and culture media development.
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Medchemexpress LLC Cilnidipine | 132203-70-4 | 99.89% | 492.52 | 1 ML
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Cilnidipine is a long-acting, second-generation dihydropyridine Ca2+-channel blocker that targets L and N-type Ca2+ channels, exhibiting antihypertensive effects. It is suitable for various laboratory applications.
- Long-acting
- Second-generation dihydropyridine Ca2+-channel blocker
- Blocks L and N-type Ca2+ channels
- Antihypertensive effects
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Alkali Scientific Super Broth, Liquid, 1 Liter
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Super Broth, Liquid, 1 Liter, is an enriched medium designed to provide optimal growth conditions for a wide variety of microorganisms. It contains additional nutrients and vitamins that support rapid cell growth, making it ideal for high-density microbial cultures. This broth is commonly used in microbiological research and biotechnology applications where enhanced cell growth is necessary, such as protein expression, fermentation, and metabolic studies. Super Broth supports a broad range of microorganisms and is widely used in molecular biology labs for cloning, plasmid propagation, and recombinant protein production, offering superior growth conditions for many bacterial strains.
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Medchemexpress LLC Fidrisertib | 2141955-96-4 | 98.2% | 562.70 g/mol | C31H42N6O4 | 10 MG
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Fidrisertib is an orally active small-molecule inhibitor of activin receptor-like kinase 2 (ALK2) used as a research reagent to study ALK/TGF-β signaling and related disease models. The compound is provided as a solid research chemical with indicated purity suitable for in vitro and preclinical research applications.
- Orally active ALK2 inhibitor, useful for studies of ALK/TGF-β pathways.
- Supplied as a solid research reagent with high reported purity.
- Relevant for oncology and fibrodysplasia ossificans progressiva research models.
- Soluble in common organic solvents such as DMSO for assay preparation.
- Provided in small research pack suitable for assay development and preclinical experiments.
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Medchemexpress LLC Natriuretic Peptides A Antibody (YA1381) | 50 UL
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Natriuretic Peptides A Antibody (YA1381) is a rabbit-derived and non-conjugated IgG monoclonal antibody, specifically targeting Natriuretic Peptides A. This antibody is stable under recommended storage conditions and is intended for research use only.
- Rabbit-derived and non-conjugated IgG monoclonal antibody
- Targets natriuretic peptides A
- Reactivity: human
- Application: WB, IP
- Molecular weight: 16 kDa
- Concentration: 0.35 mg/mL
- Formulation: 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% glycerol, 0.01% sodium azide and 0.05% BSA
- Stored at -20°C for 1 year, avoid repeated freeze/thaw cycles
- Shipped with blue ice
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Medchemexpress LLC Casein kinase 1delta-IN-3 | 349438-77-3 | 99.50% | 312.39 | 5 MG
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Casein kinase 1delta-IN-3 (Compound 23a) is a potent and selective inhibitor of casein kinase 1 delta (CK1d) with a pIC50 of 6.5376 M. This compound serves as a valuable reference in research settings.
- Potent and selective CK1d inhibitor
- pIC50 of 6.5376 M
- Useful as a reference compound
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Medchemexpress LLC Luteinizing Hormone beta Antibody (YA1095) | 50 UL
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Luteinizing Hormone beta Antibody (YA1095) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, specifically targeting Luteinizing Hormone beta. It is for research use only.
- Rabbit-derived IgG monoclonal antibody
- Targets Luteinizing Hormone beta
- Predicted band size: 16 kDa
- Observed band size: 19 kDa
- Species reactivity: Human
- Purity: Affinity purified
- Non-conjugated
- Formulation: Supplied in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA
- For research use only
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Medchemexpress LLC Ligustroflavone | 260413-62-5 | 724.66 | 1 MG
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Ligustroflavone is an orally active flavonoid compound extracted from Ligustrum lucidum. It acts as a calcium-sensing receptor (CaSR) antagonist, inhibits the RIPK1/RIPK3/MLKL pathway, and downregulates TGF-β/Smad signaling. It regulates calcium metabolism, protects bone tissue, reduces cerebral ischemic injury, and inhibits liver fibrosis.
- Regulates calcium metabolism
- Protects bone tissue
- Reduces cerebral ischemic injury
- Inhibits liver fibrosis
- Antagonizes the calcium-sensing receptor (CaSR)
- Inhibits the RIPK1/RIPK3/MLKL pathway
- Downregulates TGF-β/Smad signaling
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Medchemexpress LLC Ezh2-IN-14 | 1979157-17-9 | 99.0% | 541.69 | 5 MG
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EZH2-IN-14 is a selective EZH2 (Histone Methyltransferase) inhibitor with an IC50 of 12 nM. It inhibits the methyltransferase activity of EZH2/PRC2, thereby reducing H3K27me3. This compound demonstrates over 200-fold selectivity for EZH2 compared to the highly homologous H3K27 methyltransferase EZH1 and is for research use only.
- Selective EZH2 inhibitor with an IC50 of 12 nM
- Inhibits methyltransferase activity of EZH2/PRC2
- Reduces H3K27me3 and H3K27me2 marks in MDA-MB-468 cells
- Demonstrates high selectivity for EZH2 over EZH1
- Shows antiproliferative activity in various human cell lines
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Medchemexpress LLC ErSO-TFPy | 3035547-78-2 | C19H13F7N2O2 | 5 MG
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ErSO-TFPy (TEQ103) is an ERα+ tumor cell inhibitor that exhibits low nanomolar cytotoxic activity against ERα+ breast cancer cells. It functions by activating the sodium channel TRPM4, which leads to an imbalance of intracellular calcium and sodium ions. This dysregulation of calcium homeostasis in ERα+ tumor cells triggers the anticipatory unfolded protein response and induces rapid immune cell-independent necrotic cell death. ErSO-TFPy is suitable for research on estrogen receptor alpha positive breast cancer.
- ERα+ tumor cell inhibitor.
- Exhibits low nanomolar cytotoxic activity against ERα+ breast cancer cells.
- Activates the sodium channel TRPM4.
- Causes an imbalance of intracellular calcium and sodium ions.
- Dysregulates calcium homeostasis in ERα+ tumor cells.
- Triggers the anticipatory unfolded protein response.
- Induces rapid immune cell-independent necrotic cell death.
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Medchemexpress LLC GRL-1720 | 2835511-03-8 | C14H11ClN2O2 | 50 MG
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GRL-1720 is a potent SARS-CoV-2 Mpro inhibitor with an EC50 value of 15 μM. It exhibits anti-SARS-CoV2 activity and has a molecular weight of 274.70.
- Potent SARS-CoV-2 Mpro inhibitor
- Exhibits anti-SARS-CoV2 activity
- EC50 value of 15 μM (SARS-CoV-2 Mpro)
- Molecular weight of 274.70
- Appearance: off-white to light yellow solid
- Purity: 98.87%
- Protected VeroE6 cells cultured with SARS-CoV-2WK-521
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Medchemexpress LLC ZIM | 301298-87-3 | C20H19N3O3 | 50 MG
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ZIM, a norbornene derived from 4-Aminoantipyrine, is a potent inducer of DNA damage, causing genomic and chromosomal damage as well as inducing cell death and activating phagocytosis. ZIM has chemotherapeutic potential for use in cancer research.
- Potent inducer of DNA damage
- Causes genomic and chromosomal damage
- Induces cell death
- Activates phagocytosis
- Chemotherapeutic potential for use in cancer research
- Can effectively reduce the frequency of chromosome micronucleus in adult male Swiss mice
- Reduces the frequency of cisplatin-CIS and doxorubicin-DOX-induced liver and kidney cell death
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